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Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases.

par Bouhtit, Fatima;Najar, Mehdi ;Rahmani, Saida;Melki, Rahma;Najimi, Mustapha;Sadki, Khalid;Boukhatem, Noreddine;Twizere, Jean-Claude;Meuleman, Nathalie ;Lewalle, Philippe ;Lagneaux, Laurence ;Merimi, Makram
Référence Inflammation research, 71, 7-8, page (887-898)
Publication Publié, 2022-08-01

Article révisé par les pairs

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Résumé :

Mesenchymal stromal cells (MSCs) are currently used in cell reparative medicine due to their trophic and ant-inflammatory properties. The modulation of stem cell properties by phytochemicals has been suggested as a tool to empower their tissue repair capacity. In vitro, MSCs are characterized by their tri-lineage potential that holds great interest for tissue regeneration. Ptychotis Verticillata (PV), an aromatic and medicinal plant, may be thus used to modulate the in vitro multilineage potential of MSCs.