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Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes.

par Kim, So Yoon;Lee, Ji-Hyeon;Merrins, Matthew MJ;Gavrilova, Oksana;Bisteau, Xavier ;Kaldis, Philipp;Satin, Leslie LS;Rane, Sushil SG
Référence The Journal of biological chemistry, 292, 9, page (3841-3853)
Publication Publié, 2017

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Titre:	Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes.
Auteur:	Kim, So Yoon; Lee, Ji-Hyeon; Merrins, Matthew MJ; Gavrilova, Oksana; Bisteau, Xavier; Kaldis, Philipp; Satin, Leslie LS; Rane, Sushil SG
Informations sur la publication:	The Journal of biological chemistry, 292, 9, page (3841-3853)
Statut de publication:	Publié, 2017
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	CDK2
	FOXO
	beta cell (B-cell)
	beta cell function
	beta cell mass
	cell cycle
	cyclin-dependent kinase (CDK)
	diabetes
	foxo1
MeSH keywords:	Animals
	Body Weight
	Cell Proliferation
	Cyclin-Dependent Kinase 2 -- genetics -- metabolism
	Diabetes Mellitus, Experimental -- pathology
	Diet, High-Fat
	Disease Progression
	Female
	Genotype
	Glucose -- chemistry
	Glucose Tolerance Test
	Humans
	Insulin -- metabolism
	Insulin Secretion
	Insulin-Secreting Cells -- cytology -- pathology
	Male
	Mice
	Mice, Knockout
	Microscopy, Fluorescence
	Pancreas -- pathology
	Phenotype
	Phosphorylation
Langue:	Anglais
Identificateurs:	urn:issn:0021-9258
	info:doi/10.1074/jbc.M116.754077
	info:pii/S0021-9258(20)34891-2
	info:pmid/28100774
	PMC5339765