Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review

Sarrand, Julie; Soyfoo, Muhammad Shahnawaz

doi:doi/10.3390/ijms23063138

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Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review

par Sarrand, Julie

;Soyfoo, Muhammad Shahnawaz

Référence International journal of molecular sciences, 23, 6, 3138
Publication Publié, 2022-03

Article révisé par les pairs

Résumé :

IL-33 is a newly discovered cytokine displaying pleiotropic localizations and functions. More specifically, it also functions as an alarmin, following its release from cells undergoing cell death or necrosis, to alert the innate immune system. The role of IL-33 has been underlined in several inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE). The expressions of IL-33 as well as its receptor, ST2, are significantly upregulated in SLE patients and in patients with lupus nephritis. This review discusses the involvement of IL-33 in the pathology of SLE.

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