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Injectable hydrogels based on silk fibroin peptide grafted hydroxypropyl chitosan and oxidized microcrystalline cellulose for scarless wound healing

par Liu, Shuang;Zhao, Yingsong;Wei, Haojie;Nie, Lei;Ding, Peng;Sun, Huixuan;Guo, Yuandong;Chen, Tiantian;Okoro, Oseweuba ;Shavandi, Amin ;Fan, Lihong
Référence Colloids and surfaces. A, Physicochemical and engineering aspects, 647, page (129062)
Publication Publié, 2022

Article révisé par les pairs

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Résumé :

Scars are consequences of the wound healing process, and eliminating scar formation remains a significant challenge. Here, an injectable HMSC hydrogel was developed based on silk fibroin peptide grafted hydroxypropyl chitosan (HPCS-g-SFP) and oxidized microcrystalline cellulose (OMCC) via Schiff base bonds. The synthesized HPCS-g-SFP copolymer displayed efficient free radical scavenging ability on hydrogen hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH). The pore size, gelling time, equilibrium swelling rate and water retention properties of HMSC hydrogel could be regulated by changing ratio of OMCC and HPCS-g-SFP. Then, tetramethylpyrazine (TMP) was encapsulated into HMSC hydrogel to obtain TMP-loaded HMSC hydrogel. The TMP-loaded HMSC hydrogel facilitated 95% cell activity retention after culturing with human skin fibroblasts (HSF) or human hypertrophic scar fibroblast (HSFB) cells for 24 h. Additionally, in vivo animal experiments confirmed that TMP-loaded HMSC hydrogel promoted rapid wound healing while preventing scar formation. The designed injectable TMP-loaded HMSC hydrogel has potentials in promoting scarless wound healing.