par Awada, Ahmad ;Berghmans, Thierry ;Clement, Paul M J P.;Cuppens, Kristof;De Wilde, Bram;Machiels, Jean Pascal;Pauwels, Patrick;Peeters, Michel ;Rottey, Sylvie;Van Cutsem, Eric
Référence Critical reviews in oncology/hematology, 169, 103564
Publication Publié, 2022-01
Référence Critical reviews in oncology/hematology, 169, 103564
Publication Publié, 2022-01
Article révisé par les pairs
Résumé : | Fusions of NTRK (neurotrophic tyrosine receptor kinase) genes with 5′ partner genes can result in the expression of chimeric proteins that drive oncogenesis through ligand-independent kinase activation. Despite variable frequencies of NTRK fusions in different tumor types, the fact that they are common to a wide range of cancers raises the possibility of developing tumor-agnostic treatments specifically targeting NTRK fusion products, irrespective of tumor type. The first-generation Trk (tropomyosin receptor kinase) inhibitor, larotrectinib, was the first tumor-agnostic treatment of NTRK fusion-positive cancers in adults and children, to be approved in the European Union. This consensus, developed by a Belgian multidisciplinary expert panel, aims to highlight the unmet medical need associated to NTRK fusion-driven cancer treatment and, based on current knowledge of NTRK fusions and larotrectinib treatment outcome and safety, provide comprehensive guidance to oncologists regarding NTRK fusion-driven cancer diagnostics and the best use of larotrectinib in real-world clinical settings. |