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Autoantibodies and SARS-CoV2 infection: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

par Damoiseaux, Jan G M C J.;Dotan, Arad;Fritzler, Marvin M.J.;Bogdanos, Dimitrios D.P.;Meroni, Pier Luigi;Roggenbuck, Dirk;Goldman, Michel ;Landegren, Nils;Bastard, Paul;Shoenfeld, Yehuda;Conrad, Karsten
Référence Autoimmunity Reviews, 21, 3, 103012
Publication Publié, 2022-03

Article révisé par les pairs

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Résumé :

The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.