Titre:
  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.
Auteur:Dentro, Stefan C; Leshchiner, Ignaty; Haase, Kerstin; Tarabichi, Maxime; Wintersinger, Jeff J.A.; Deshwar, Amit G; Yu, Kaixian; Rubanova, Yulia; Macintyre, Geoff; Demeulemeester, Jonas; Vázquez-García, Ignacio; Kleinheinz, Kortine; Livitz, Dimitri G; Malikic, Salem; Donmez, Nilgun; Sengupta, Subhajit; Anur, Pavana; Jolly, Clemency; Cmero, Marek; Rosebrock, Daniel; Schumacher, Steven; Fan, Yu; Fittall, Matthew; Drews, Ruben M; Yao, Xiaotong; Watkins, Thomas B K; Lee, Juhee; Schlesner, Matthias; Zhu, Hongtu; Adams, David J; McGranahan, Nicholas; Swanton, Charles; Getz, Gad; Boutros, Paul C; Imielinski, Marcin; Beroukhim, Rameen; Sahinalp, Cenk; Ji, Yuan; Peifer, Martin; Martincorena, Inigo; Markowetz, Florian; Mustonen, Ville; Yuan, Ke; Gerstung, Moritz; Spellman, Paul T; Wang, Wenyi; Morris, Quaid D.; Wedge, David C; Van Loo, Peter
Informations sur la publication:Cell, 184, 8, page (2239-2254.e39)
Statut de publication:Publié, 2021-02-01
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:branching evolution
cancer driver genes
cancer evolution
intra-tumor heterogeneity
pan-cancer genomics
subclonal reconstruction
tumor phylogeny
whole-genome sequencing
MeSH keywords:DNA Copy Number Variations
DNA, Neoplasm -- chemistry -- metabolism
Databases, Genetic
Drug Resistance, Neoplasm -- genetics
Genetic Heterogeneity
Humans
Neoplasms -- genetics -- pathology
Polymorphism, Single Nucleotide
Whole Genome Sequencing
Langue:Anglais
Identificateurs:urn:issn:0092-8674
info:doi/10.1016/j.cell.2021.03.009
info:pii/S0092-8674(21)00294-4
info:pmid/33831375
PMC8054914