par Singh, Anurag 
;Jabin, Ivan ;Valkenier, Hennie
Référence EDT-CHIM 2021 (20th May 2021)
Publication Non publié, 2021-05-20
;Jabin, Ivan ;Valkenier, Hennie Référence EDT-CHIM 2021 (20th May 2021)
Publication Non publié, 2021-05-20
Communication à un colloque
| Résumé : | Cystic fibrosis is a life-threatening disease caused by the mutation in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, affecting chloride transport across cell membranes. One of the potential solutions is to utilize synthetic anion transporters (anionophores) for restoring the chloride transport process. The vast majority of reported synthetic chloride transporters use hydrogen bonds (HB) as an interaction between chloride and the anionophore. In our work, we employed halogen bond (XB) donating groups on a calix[6]arene backbone to obtain anion receptors. XBs can have comparable strength to HBs, but XB donors do not have acidic H-atoms, as they interact with anions using halogen atoms. This makes XB-based anionophores potentially less toxic than anionophores relying on HBs, as they are less likely to dissipate pH gradients. A series of calixarene-based molecules were designed and synthesized to screen them for anion transport. One of our molecules was able to selectively transport chloride over protons. In this flash presentation, I will give an overview of the studied calixarene molecules and their anion transport abilities. |
