Antibodies to post-translationally modified insulin in type 1 diabetes.

Strollo, Rocky; Vinci, Chiara; Arshad, Mayda H; Perrett, David; Tiberti, Claudio; Chiarelli, Francesco; Napoli, Nicola; Pozzilli, Paolo; Nissim, Ahuva

doi:doi/10.1007/s00125-015-3746-x

Recherche avancée | Historique de recherche Mon DI-fusion | À propos de DI-fusion | Contact |

Citer

Antibodies to post-translationally modified insulin in type 1 diabetes.

par Strollo, Rocky ;Vinci, Chiara

;Arshad, Mayda H ;Perrett, David ;Tiberti, Claudio ;Chiarelli, Francesco ;Napoli, Nicola ;Pozzilli, Paolo ;Nissim, Ahuva
Référence Diabetologia, 58, 12, page (2851-2860)
Publication Publié, 2015-12

Article révisé par les pairs

Résumé :

Insulin is the most specific beta cell antigen and a potential primary autoantigen in type 1 diabetes. Insulin autoantibodies (IAAs) are the earliest marker of beta cell autoimmunity; however, only slightly more than 50% of children and even fewer adults newly diagnosed with type 1 diabetes are IAA positive. The aim of this investigation was to determine if oxidative post-translational modification (oxPTM) of insulin by reactive oxidants associated with islet inflammation generates neoepitopes that stimulate an immune response in individuals with type 1 diabetes.

Documents en relation

DI-fusion

Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
par Strollo, Rocky , Vinci, Chiara , Man, Y. K. Stella , Bruzzaniti, Sara , Piemonte, Erica , Alhamar, Ghadeer , Briganti, Silvia Irina , Malandrucco, Ilaria , Tramontana, Flavia , Fanali, Chiara , Garnett, James , Buccafusca, Roberto , Guyer, Perrin , Mamula, Mark M.J. , James, Eddie E.A. , Pozzilli, Paolo , Ludvigsson, Johnny , Winyard, Paul , Galgani, Mario , Nissim, Ahuva
Publication 2022-10
Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children.
par Strollo, Rocky , Vinci, Chiara , Napoli, Nicola , Pozzilli, Paolo , Ludvigsson, Johnny , Nissim, Ahuva
Publication 2017
Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet autoantibodies.
par Strollo, Rocky , Vinci, Chiara , Napoli, Nicola , Fioriti, Elvira , Maddaloni, Ernesto , Åkerman, Linda , Casas, Rosaura , Pozzilli, Paolo , Ludvigsson, Johnny , Nissim, Ahuva
Publication 2019-01-01
Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death
par Roca Rivada, Arturo , Marin Canas, Sandra , Colli, Maikel Luis , Vinci, Chiara , Sawatani, Toshiaki , Marselli, Lorella , Cnop, Miriam , Marchetti, Piero , Eizirik, Décio L
Publication 2023-08-01
Ionizing radiation responses appear incidental to desiccation responses in the bdelloid rotifer Adineta vaga
par Moris, Victoria , Bruneau, Lucie , Berthe, Jérémy , Heuskin, Anne-Catherine , Penninckx, Sébastien , Ritter, Sylvia , Weber, Uli , Durante, Marco , Danchin, Etienne E.G.J. , Hespeels, Boris , Doninck, Karine Van
Publication 2024-12

Référencement	Visibilité	Pérennité	Facilité
Les publications encodées constituent la bibliographie académique de l'Université.	Les documents déposés sont indexés par les moteurs de recherche (Google Scholar,…).	Les documents déposés en open-access sont archivés au sein du réseau de préservation SAFE-PLN (www.safepln.org).	Les listes de publications sont compatibles avec le CV-ULB, le FNRS et accessibles sur le web.