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Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature

par Catherine, Julien ;Jungels, C.;Durieux, Valérie ;Deliens, Coralie;Grigoriu, Bogdan
Référence Frontiers in oncology, 11, 694620
Publication Publié, 2021-11

Article révisé par les pairs

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Résumé :

New drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metastatic solitary fibrous tumor, we performed a systematic review of the literature encompassing the results of previous cardiac safety analysis published ten years ago, a review of clinical trials published during the last 10 years as well as single-case descriptions related to trabectedin cardiotoxicity. The estimated incidence of cardiac toxicity was 3,4% among patients receiving trabectedin, with recent data suggesting a higher rate of heart failure than previously recognized. Previous or concomitant anthracyclines exposure may represent a risk factor. Assaying for NT-pro-BNP may be useful for the early detection of individuals with trabectedin-induced heart failure.