METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR

Raspé, Eric; Roger, Pierre P.; Coulonval, Katia; Paternot, Sabine; Pita, Jaime Miguel; Sotiriou, Christos; Ignatiadis, Michail; Rothé, Françoise

Recherche avancée | Historique de recherche Mon DI-fusion | À propos de DI-fusion | Contact |

Citer

METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR

par Raspé, Eric

Publication Publié, 2021-04-14

Brevet

Résumé :

The present invention relates to methods for determining sensitivity to a cyclin dependent kinase 4 or 6 (CDK4/6) inhibitor in a human subject having breast cancer. The present invention provides a gene expression signature as a companion diagnostic to a CDK4/6 inhibitor that allows determining whether a human subject having breast cancer will benefit from treatment with a CDK4/6 inhibitor or whether the subject has no direct clinical benefit from such treatment or whether the subject will be insensitive to the drug.

Documents en relation

DI-fusion

METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR
par Raspé, Eric , Roger, Pierre P. , Coulonval, Katia , Paternot, Sabine , Pita, Jaime Miguel , Sotiriou, Christos , Ignatiadis, Michail , Rothé, Françoise
Publication 2019-11-14
Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27.
par Coulonval, Katia , Vercruysse, Vincent , Paternot, Sabine , Pita, Jaime Miguel , Corman, Robert , Raspé, Eric , Roger, Pierre P.
Publication 2022-01-21
Circulating tumor DNA validity and potential uses in metastatic breast cancer
par Amato, Ottavia , Giannopoulou, Nefeli , Ignatiadis, Michail
Publication 2024-12
CDK4/6 Inhibitors in Pancreatobiliary Cancers: Opportunities and Challenges
par Arsenijevic, Tatjana , Coulonval, Katia , Raspé, Eric , Demols, Anne , Roger, Pierre P. , Van Laethem, Jean-Luc
Publication 2023-02-01
Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implications.
par Wang, Xiaoxiao , Venet, David , Lifrange, Frédéric , Larsimont, Denis , Rediti, Mattia , Stenbeck, Linnea , Dupont, Floriane , Rouas, Ghizlane , Garcia, Andrea Joaquin , Craciun, Ligia , Buisseret, Laurence , Ignatiadis, Michail , Carausu, Marcela , Bhalla, Nayanika , Masarapu, Yuvarani , Villacampa, Eva Gracia , Franzén, Lovisa , Saarenpää, Sami , Kvastad, Linda , Thrane, Kim , Lundeberg, Joakim , Rothé, Françoise , Sotiriou, Christos
Publication 2024-11

Référencement	Visibilité	Pérennité	Facilité
Les publications encodées constituent la bibliographie académique de l'Université.	Les documents déposés sont indexés par les moteurs de recherche (Google Scholar,…).	Les documents déposés en open-access sont archivés au sein du réseau de préservation SAFE-PLN (www.safepln.org).	Les listes de publications sont compatibles avec le CV-ULB, le FNRS et accessibles sur le web.