• Citer

Belgian consensus recommendations to prevent vitamin k deficiency bleeding in the term and preterm infant

par Fiesack, Simon;Smits, Anne;Rayyan, Maissa;Allegaert, Karel;Alliet, Philippe;Arts, Wim;Bael, An;Cornette, Luc;De Guchtenaere, Ann;De Mulder, Nele;George, Isabel;Henrion, Elisabeth;Keiren, Kirsten;Kreins, Nathalie;Raes, Marc;Philippet, Pierre;Van Overmeire, Bart ;Van Winckel, Myriam;Vlieghe, Vinciane ;Vandenplas, Yvan
Référence Nutrients, 13, 11, 4109
Publication Publié, 2021-11

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns.