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Non-clinical assessment of lubrication and free radical scavenging of an innovative non-animal carboxymethyl chitosan biomaterial for viscosupplementation: An in-vitro and ex-vivo study.

par Vandeweerd, Jean Michel;Innocenti, Bernardo ;Rocasalbas, Guillem;Gautier, Sandrine Emilia;Douette, Pierre;Hermitte, Laurence;Hontoir, Fanny;Chausson, Mickael
Référence PloS one, 16, 10, page (e0256770)
Publication Publié, 2021

Article révisé par les pairs

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Résumé :

Lubrication and free radical scavenging are key features of biomaterials used for viscosupplementation (VS) of joints affected by osteoarthritis (OA). The objective of this study was to describe the non-clinical performance characterization of KiOmedine® CM-Chitosan, a non-animal carboxymethyl chitosan, in order to assess its intended action in VS and to compare it to existing viscosupplements based on crosslinked hyaluronan (HA) formulations.