par Despin-Guitard, Evangeline 
;Migeotte, Isabelle
Référence Cell cycle (Georgetown, Tex.), page (1-13)
Publication Publié, 2021-10
;Migeotte, Isabelle Référence Cell cycle (Georgetown, Tex.), page (1-13)
Publication Publié, 2021-10
Article révisé par les pairs
| Résumé : | Mitosis is a key process in development and remains critical to ensure homeostasis in adult tissues. Besides its primary role in generating two new cells, cell division involves deep structural and molecular changes that might have additional effects on cell and tissue fate and shape. Specific quantitative and qualitative regulation of mitosis has been observed in multiple morphogenetic events in different embryo models. For instance, during mouse embryo gastrulation, the portion of epithelium that undergoes epithelial to mesenchymal transition, where a static epithelial cell become mesenchymal and motile, has a higher mitotic index and a distinct localization of mitotic rounding, compared to the rest of the tissue. Here we explore the potential mechanisms through which mitosis may favor tissue reorganization in various models. Notably, we discuss the mechanical impact of cell rounding on the cell and its environment, and the modification of tissue physical parameters through changes in cell-cell and cell-matrix adhesion. |
