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Sex differences in alveolar macrophages polarization during Streptococcus agalactiae-Induced pneumoniae

par Deny, Maud ;Romano, Márta ;Denis, Olivier ;Casimir, Georges ;Chamekh, Mostafa
Référence 6th European Congress of Immunology(01 septembre 2021: hosted by Turkish society of immunology (virtual)), Communication, European Journal of Immunology, Vol. 51, page (349)
Publication Publié, 2021-09-01

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Résumé :

Body of clinical and experimental investigations clearly indicate that sex is a contributing factor in the incidence and progression of several infectious diseases. This is particularly observed in respiratory diseases where men present higher morbidity and mortality than in women along the life course. We study the differences between the sexes in the inflammatory response in mice model of pulmonary group B streptococcus (GBS) infection. We found that the dynamics of pulmonary infiltration of alveolar macrophages differ between males and females after intranasal infection of GBS. This is associated with higher local production of the primary pro-inflammatory cytokines IL-1β and TNFα and higher expression of the chemokines CXCL2 and CCL3 in males compared to females. Alveolar macrophages represent a heterogeneous cell population and exhibit remarkable plasticity. In response to distinct micro-environmental stimuli, macrophages can polarize into different cell subtypes: classically activated macrophages (M1), involved in the pro-inflammatory process and in tissue damage, and alternatively activated macrophages (M2), involved in the damping of inflammation and tissue repair. We found that macrophages from GBS-infected male mice expressed higher levels of M1 macrophages markers (iNOS ans CD80). Taken together, our results indicate a differential sex polarization of alveolar macrophages during pulmonary GBS infection, hence suggesting the contribution of M1 macrophages in increased airway inflammation found in male mice.