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Roles of Myeloperoxidase in the Oxidation of Apolipoproteins: Interest of Monitoring Myeloperoxidase Oxidation of Apolipoproteins A-1 and B-100 to Improve the Estimation of Lipoprotein Quality in Cardiovascular Diseases

par Coremans, Catherine ;Zouaoui Boudjeltia, Karim ;Van Antwerpen, Pierre ;Delporte, Cédric
Editeur scientifique Hawkins, Clare C.L.;Nauseef, William W. M.
Référence Mammalian Heme Peroxidases, CRC Press, Boca Raton, Ed. 1, page (340)
Publication Publié, 2021-10-08

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Résumé :

For almost 30 years, researchers have investigated the impact of oxidation of first low-density lipoproteins (LDLs) and then of high-density lipoproteins (HDLs) in pathology. The involvement of myeloperoxidase (MPO) in the oxidation process of these lipoproteins has appeared to play a key role in cardiovascular disease (CVD), such as atherosclerosis. Indeed, it is now confirmed that MPO adsorbs on lipoproteins and specifically modifies them, generating pro-atherogenic lipoproteins commonly named Mox-LDLs and Mox-HDLs. In this chapter, the role of MPO in the contribution to modifications of LDLs and HDLs is discussed as well as its roles in cardiovascular disease development linked to oxidized lipoproteins.