par Fouotsa, Hugues;Le Pogam, Pierre;Mkounga, Pierre;Lannang, Alain Meli;Bernadat, Guillaume;Vanheuverzwijn, Jérôme 
;Zhou, Zhiyu ;Leblanc, Karine;Rharrabti, Somia;Nkengfack, Augustin Ephrem;Gallard, Jean-François;Fontaine, Véronique ;Meyer, Franck ;Poupon, Erwan;Beniddir, Mehdi
Référence Journal of natural products
Publication Publié, 2021-09
;Zhou, Zhiyu ;Leblanc, Karine;Rharrabti, Somia;Nkengfack, Augustin Ephrem;Gallard, Jean-François;Fontaine, Véronique ;Meyer, Franck ;Poupon, Erwan;Beniddir, MehdiRéférence Journal of natural products
Publication Publié, 2021-09
Article révisé par les pairs
| Résumé : | Voatriafricanines A and B (1 and 2), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana, guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity. |
