par Claeys, M.A. M.A.;Camu, Frédéric 
;Maes, Viviane
Référence Acta anaesthesiologica Scandinavica, 36, 3, page (270-275)
Publication Publié, 1992
;Maes, Viviane Référence Acta anaesthesiologica Scandinavica, 36, 3, page (270-275)
Publication Publié, 1992
Article révisé par les pairs
| Résumé : | The influence of diclofenac, given by continuous i.v. infusion starting preoperatively, on postoperative pain and inflammation was assessed in a double‐blind, randomized, placebo‐controlled study in 40 patients scheduled for major orthopedic surgery. Starting 30 min before induction the patients received either diclofenac (0.35 mg.kg‐1 bolus followed by a constant‐rate infusion of 90 μ.min‐1) or placebo for 24 h. The pain intensity (VAS) and the amount of rescue narcotic (piritramide on demand) were significantly lower in the diclofenac group from 4 and 6 h postsurgery, respectively, till end of infusion. Acute phase proteins used as inflammation markers (C‐reactive protein, α1‐chymotrypsin, α1‐acid glycoprotein, haptoglobin and coeruloplasmin) showed similar variations in both groups for 24 h. The diclofenac treatment had no influence on hematological and coagulation profiles, nor on muscle and liver enzymes in comparison with placebo. Both patients and observer rated the diclofenac treatment as significantly superior to the placebo treatment. © 1992 Acta Anaesthesiologica Scandinavica Fonden |
