Update on functional inhibitors of acid sphingomyelinase (Fiasmas) in sars-cov-2 infection

Loas, Gwenolé; Le Corre, Pascal

doi:doi/10.3390/ph14070691

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Update on functional inhibitors of acid sphingomyelinase (Fiasmas) in sars-cov-2 infection

par Loas, Gwenolé

;Le Corre, Pascal
Référence Pharmaceuticals, 14, 7, 691
Publication Publié, 2021-07

Article révisé par les pairs

Résumé :

The SARS-CoV-2 outbreak is characterized by the need of the search for curative drugs for treatment. In this paper, we present an update of knowledge about the interest of the functional inhibitors of acid sphingomyelinase (FIASMAs) in SARS-CoV-2 infection. Forty-nine FIASMAs have been suggested in the treatment of SARS-CoV-2 infection using in silico, in vitro or in vivo studies. Further studies using large-sized, randomized and double-blinded controlled clinical trials are needed to evaluate FIASMAs in SARS-CoV-2 infection as off-label therapy.

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