par Alafandy, Mokarram;Goffinet, Gérhard;Umbrain, Vincent;D'Haese, Jan;Camu, Frédéric 
;Legros, Franz Jacques
Référence Nuclear medicine and biology, 23, 7, page (881-887)
Publication Publié, 1996-10
;Legros, Franz Jacques Référence Nuclear medicine and biology, 23, 7, page (881-887)
Publication Publié, 1996-10
Article révisé par les pairs
| Résumé : | Liposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen-free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with 99mTc attained 98% of the added radioactivity. Thirty percent 99mTc were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37°C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies. |
