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Biological and clinical features of triple negative Invasive Lobular Carcinomas of the breast. Clinical outcome and actionable molecular alterations.

par Conforti, Fabio;Pala, Laura;Pagan, Eleonora;Rocco, Elena Guerini;Bagnardi, Vincenzo;Montagna, Emilia;Peruzzotti, Giulia;De Pas, Tommaso;Fumagalli, Caterina;Pileggi, Silvana;Pesenti, Chiara;Marchini, Sergio;Corso, Giovanni;Marchio', Caterina;Sapino, Anna;Graffeo, Rossella;Collet, Laetitia ;Aftimos, Philippe ;Sotiriou, Christos ;Piccart, Martine;Gelber, Richard D;Viale, Giuseppe;Colleoni, Marco Angelo;Goldhirsch, Aron
Référence Breast, 59, page (94-101)
Publication Publié, 2021-06-01

Article révisé par les pairs

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Résumé :

We report here for the first time, a comprehensive characterization of biological and clinical features of early-stage triple negative Invasive Lobular Carcinomas(TN-ILCs) METHODS: We analyzed all consecutive patients with early-stage TN-ILC operated at two reference cancer-centers between 1994 and 2012. Primary objective was to assess the invasive disease-free survival(iDFS). Co-primary objective was to assess biological features of TN-ILCs, including molecular intrinsic subtypes based on PAM-50 assay, expression of androgen receptor (AR) and mutational status of ERBB2-gene. Additionally, DNA mutational status of an independent cohort of 45 TN-ILCs from three databases were analyzed, to confirm mutations in ERBB2-gene and to identify other recurrently mutated genes.