par Marloye, Mickaël ;Inam, Haider;Moore, Connor J;Debaille, Vinciane ;Pritchard, Justin JR;Gelbcke, Michel ;Meyer, Franck ;Dufrasne, François ;Berger, Gilles
Référence JBIC. Journal of biological inorganic chemistry
Publication Publié, 2021-06-01
Référence JBIC. Journal of biological inorganic chemistry
Publication Publié, 2021-06-01
Article révisé par les pairs
Résumé : | Ruthenium (Ru) and osmium (Os) complexes are of sustained interest in cancer research and may be alternative to platinum-based therapy. We detail here three new series of ruthenium and osmium complexes, supported by physico-chemical characterizations, including time-dependent density functional theory, a combined experimental and computational study on the aquation reactions and the nature of the metal-arene bond. Cytotoxic profiles were then evaluated on several cancer cell lines although with limited success. Further investigations were, however, performed on the most active series using a genetic approach based on RNA interference and highlighted a potential multi-target mechanism of action through topoisomerase II, mitotic spindle, HDAC and DNMT inhibition. |