par Barzegar-fallah, Anita;Houlton, Josh;Barwick, Deanna;Shavandi, Amin 
;Azam Ali, M.;Clarkson, Andrew A.N.;Alimoradi, Houman
Référence Theory and Applications of Nonparenteral Nanomedicines, Academic Press, page (467-487)
Publication Publié, 2021
;Azam Ali, M.;Clarkson, Andrew A.N.;Alimoradi, HoumanRéférence Theory and Applications of Nonparenteral Nanomedicines, Academic Press, page (467-487)
Publication Publié, 2021
Partie d'ouvrage collectif
| Résumé : | The minimal therapeutic impact observed following nanoparticle delivery directly correlates to the inability of nanoparticles to overcome biological barriers such as mucosal membranes and glycocalyx, cell membranes and cellular internalization, clearance by immune cells and accumulation in liver and spleen, and hemorheology of blood and drug resistance. In most nonparenteral drug-delivery systems, the mucosal barrier and glycocalyx play the first and arguably the most important barrier. The major components of the glycocalyx, glycans, surround all cells, actuate responses to growth factors, cytokines, and morphogens, resulting in changes in downstream signaling pathways and gene expression. They are important components or key players in all biological barriers and can impact nonparenteral delivery systems. In this chapter, we discuss biological barriers that create hurdle for efficient drug delivery to the site of action focusing on nonparenteral delivery systems, glycocalyx and mucosal barrier, biochemistry of glycans, and the role they play within the biological barriers. Understanding the structure and function of glycans and their impact on the barriers that limit drug delivery, may pave the way for the design of novel nonparental delivery systems. |
