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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.

par Galmarini, Carlos M;Martin, Maud ;Bouchet, Benjamin Pierre;Guillen-Navarro, María José;Martínez-Diez, Marta;Martinez-Leal, Juan Fernando;Akhmanova, Anna;Aviles, Pablo
Référence BMC cancer, 18, 1, page (164)
Publication Publié, 2018-05-01

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Titre:	Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.
Auteur:	Galmarini, Carlos M; Martin, Maud; Bouchet, Benjamin Pierre; Guillen-Navarro, María José; Martínez-Diez, Marta; Martinez-Leal, Juan Fernando; Akhmanova, Anna; Aviles, Pablo
Informations sur la publication:	BMC cancer, 18, 1, page (164)
Statut de publication:	Publié, 2018-05-01
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Angiogenesis inhibitors
	Cancer treatment
	Endothelial cells
	Plocabulin (PM060184)
	Tubulin inhibitors
	Vascular-disrupting agents
MeSH keywords:	Animals
	Cell Line
	Cell Line, Tumor
	Cell Movement -- drug effects
	Female
	Human Umbilical Vein Endothelial Cells -- drug effects -- metabolism -- physiology
	Humans
	Mice, Nude
	Microtubules -- drug effects -- metabolism
	Neoplasms -- blood supply -- drug therapy -- pathology
	Neovascularization, Pathologic -- prevention & control
	Neovascularization, Physiologic -- drug effects
	Polyketides -- metabolism -- pharmacology
	Protein Binding
	Pyrones -- metabolism -- pharmacology
	Tubulin -- metabolism
	Tumor Burden -- drug effects
	Xenograft Model Antitumor Assays
Langue:	Anglais
Identificateurs:	urn:issn:1471-2407
	info:doi/10.1186/s12885-018-4086-2
	info:pii/10.1186/s12885-018-4086-2
	info:pmid/29415678
	PMC5803861