par Artesi, Maria;Hahaut, Vincent;Cole, Basiel;Lambrechts, Laurens;Ashrafi, Fereshteh;Marçais, Ambroise;Hermine, Olivier;Griebel, Philip;Arsic, Natasa;van der Meer, Frank;Burny, Arsène 
;Bron, Dominique ;Bianchi, Elettra;Delvenne, Philippe O;Bours, Vincent;Charlier, Carole;Georges, Michel;Vandekerckhove, Linos;Van Den Broeke, Anne ;Durkin, Keith
Référence Genome biology, 22, 1, 97
Publication Publié, 2021-12
;Bron, Dominique ;Bianchi, Elettra;Delvenne, Philippe O;Bours, Vincent;Charlier, Carole;Georges, Michel;Vandekerckhove, Linos;Van Den Broeke, Anne ;Durkin, Keith Référence Genome biology, 22, 1, 97
Publication Publié, 2021-12
Article révisé par les pairs
| Résumé : | The integration of a viral genome into the host genome has a major impact on the trajectory of the infected cell. Integration location and variation within the associated viral genome can influence both clonal expansion and persistence of infected cells. Methods based on short-read sequencing can identify viral insertion sites, but the sequence of the viral genomes within remains unobserved. We develop PCIP-seq, a method that leverages long reads to identify insertion sites and sequence their associated viral genome. We apply the technique to exogenous retroviruses HTLV-1, BLV, and HIV-1, endogenous retroviruses, and human papillomavirus. |
