par Wauthoz, Nathalie 
;Amighi, Karim
Référence Pulmonary Drug Delivery: Advances and Challenges, wiley, page (87-121)
Publication Publié, 2015-01
;Amighi, Karim Référence Pulmonary Drug Delivery: Advances and Challenges, wiley, page (87-121)
Publication Publié, 2015-01
Partie d'ouvrage collectif
| Résumé : | Poorly water-soluble drugs represent the major part of the current and future market. Drug insolubility could impair the absorption through biological membranes and/or the pharmacological action of the drug. To overcome these issues, diverse formulation strategies to improve solubility/dissolution properties have been first developed for the conventional oral and parenteral routes. Last decades, pulmonary drug delivery becomes the gold standard treatment for the major respiratory disorders and has gained interest for systemic drug delivery. Therefore, formulation strategies were applied to poorly water-soluble drugs delivered by inhalation. This chapter focuses on the in vivo fate of poorly water-soluble drugs deposited in the lung, and the resulting lung and systemic pharmacokinetics. Then, the factors that can be implemented to improve localized or to optimize the systemic delivery of such drugs are discussed. Finally, the main formulation strategies for improving dissolution/solubility properties of inhaled poorly water-soluble drugs are described in regard to the lung or systemic delivery. |
