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Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.

par Ceolin, Lucieli;Siqueira, Débora Rodrigues;Ferreira, Carla Vaz;Romitti, Mirian ;Maia, Silvana Cavalcante;Leiria, Leonardo;Crispim, Daisy;Ashton-Prolla, Patrícia;Prolla, Patrícia Ashton;Maia, Ana Luiza
Référence European journal of endocrinology, 166, 5, page (847-854)
Publication Publié, 2012-05

Article révisé par les pairs

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Résumé :

RET single nucleotide polymorphisms (SNPs) have been implicated in the pathogenesis and progression of medullary thyroid carcinoma (MTC). Here, we investigated the influence of multiple RET variants (G691S, L769L, S836S, and S904S) on the risk of MTC and tumor behavior.