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Autoantibodies against type I IFNs in patients with life-threatening COVID-19

par Bastard, Paul;Rosen, Lindsey B.;Zhang, Qian;Michailidis, Eleftherios;Hoffmann, Hans-Heinrich;Zhang, Yu;Dorgham, Karim;Philippot, Quentin;Rosain, Jérémie;Béziat, Vivien;Manry, Jérémy;Shaw, Elana;Haljasmägi, Liis;Peterson, Pärt;Lorenzo, Lazaro;Bizien, Lucy;Trouillet-Assant, Sophie;Dobbs, Kerry;de Jesus, Adriana Almeida;Belot, Alexandre;Kallaste, Anne;Catherinot, Emilie;Tandjaoui-Lambiotte, Yacine;Le Pen, Jeremie;Kerner, Gaspard;Bigio, Benedetta;Seeleuthner, Yoann;Yang, Rui;Bolze, Alexandre;Spaan, András;Delmonte, Ottavia;Abers, Michael S.;Aiuti, Alessandro;Casari, Giorgio;Lampasona, Vito;Piemonti, Lorenzo;Ciceri, Fabio;Bilguvar, Kaya;Lifton, Richard;Vasse, Marc;Smadja, Didier;Migaud, Mélanie;Hadjadj, Jérome;Terrier, Benjamin;Duffy, Darragh;Quintana-Murci, Lluis;van de Beek, Diederik;Roussel, Lucie;Vinh, Donald C.;Tangye, Stuart;Haerynck, Filomeen;Dalmau, David;Martinez-Picado, Javier;Brodin, Petter;Nussenzweig, Michel;Boisson-Dupuis, Stéphanie;Rodríguez-Gallego, Carlos;Vogt, Guillaume;Mogensen, Trine;Oler, Andrew;Gu, Jingwen;Burbelo, Peter;Cohen, Jeffrey I.;Biondi, Andrea;Bettini, Laura Rachele;D'Angio, Mariella;Bonfanti, Paolo;Rossignol, Patrick;Mayaux, Julien;Rieux-Laucat, Frédéric;Husebye, Eystein;Fusco, Francesca;Ursini, Matilde Valeria;Imberti, Luisa;Sottini, Alessandra;Paghera, Simone;Quiros-Roldan, Eugenia;Rossi, Camelia ;Castagnoli, Riccardo;Montagna, Daniela;Licari, Amelia;Marseglia, Gian Luigi;Duval, Xavier;Ghosn, Jade;Tsang, John S.;Goldbach-Mansky, Raphaela;Kisand, Kai;Lionakis, Michail;Puel, Anne;Zhang, Shen Ying;Holland, Steven;Gorochov, Guy;Jouanguy, Emmanuelle;Rice, Charles M.;Cobat, Aurélie;Notarangelo, Luigi D.;Abel, Laurent;De Suremain, Hugues;Casanova, Jean-Laurent
Référence Science, 370, 6515, page (eabd4585)
Publication Publié, 2020-10

Article révisé par les pairs

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Résumé :

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.