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Phylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcome.

par Venet, David ;Fimereli, Danai ;Rothé, Françoise ;Boeckx, Bram;Maetens, Marion ;Majjaj, Samira ;Rouas, Ghizlane;Capra, Maria;Bonizzi, Giuseppina;Contaldo, Federica;Galant, Christine;Piccart, Martine;Pruneri, Giancarlo;Larsimont, Denis ;Lambrechts, Diether;Desmedt, Christine ;Sotiriou, Christos
Référence EBioMedicine, 56, page (102793)
Publication Publié, 2020-06-01

Article révisé par les pairs

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Résumé :

In breast cancer (BC), axillary lymph node (ALN) involvement is one of the strongest adverse prognostic factors. However, it is unclear whether loco-regional lymph node deposits are effectively the root of secondary metastases or only an indicator of competence of the primary tumour to spread to distant organs.