par Martinez Crespo, Luis 
;Halgreen, Lau ;Valkenier, Hennie
Référence NanoScience Days (8-9 October 2019: Jyväskylä, Finland)
Publication Publié, 2019-10-08
;Halgreen, Lau ;Valkenier, Hennie Référence NanoScience Days (8-9 October 2019: Jyväskylä, Finland)
Publication Publié, 2019-10-08
Poster de conférence
| Résumé : | Dysfunctional natural transmembrane transporters have been recognised as the cause of different genetic diseases (e.g. cystic fibrosis is caused by deficient chloride transport). Therefore, artificial compounds able to efficiently replace the dysfunctional proteins could be used to treat those diseases. This has encouraged chemists to develop several synthetic anion transporters, which have been prepared mainly by conventional organic synthesis.[1] These molecules usually have hydrogen bonding donor groups that permit the formation of a complex with the anion to be transported, acting as mobile carriers (Figure 1a).On the other hand, dynamic combinatorial chemistry (DCC) permits the development of structurally complex receptors from simple building blocks able to form dynamic covalent bonds.[2][3] We have designed and prepared different anion receptors containing some of these dynamic bonds (e.g. hydrazones). The transport properties of the compounds have been studied using a well stablished assay where a chloride sensitive fluorescent dye (lucigenin) is encapsulated in liposomes, which are used as artificial cell membrane models (Figure 1b). This system permits to study how the compounds present in the bilayer membrane of the liposomes induce the transport of extravesicular chloride.This work aims to open a new range of possibilities for the development of structurally complex transmembrane transporters. |
