par Valkenier, Hennie
Référence CHAINS (8-9 December 2020: online)
Publication Non publié, 2020-12-09
Communication à un colloque
Résumé : Absence or malfunction of membrane proteins forming ion channels is the cause of several channelopathies, such as cystic fibrosis. Synthetic ion carriers could take over the function of these proteins. Such carriers extract the ion from the aqueous phase, move it across the apolar interior of the lipid bilayer while shielding its charge, to then release it on the other side of the membrane. Macrocyclic receptors are preorganised, often leading to remarkable selectivities in binding and hence unique behaviour in ion transport. This will be demonstrated for bambusuril macrocycles functioning as bicarbonate transporter and calix[4]arenes capable of transporting copper(I) cations.