par Singh, Anurag 
;Jabin, Ivan ;Valkenier, Hennie
Référence CHAINS 2020 (8th - 9th December 2020: Netherlands)
Publication Non publié, 2020-12-08
;Jabin, Ivan ;Valkenier, Hennie Référence CHAINS 2020 (8th - 9th December 2020: Netherlands)
Publication Non publié, 2020-12-08
Poster de conférence
| Résumé : | Cystic fibrosis is a life-threatening disease caused by the mutation in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, affecting chloride transport across cell membranes. One of the potential solutions is to utilize synthetic anion transporters (anionophores) for restoring the chloride transport process. The vast majority of reported synthetic chloride transporters use hydrogen bonds (HB) as an interaction between chloride and the anionophore. These molecules generally have acidic H-atoms that makes them dissipate pH gradients, which could lead to toxicity.In our work, we employed halogen bond (XB) donating groups on a calixarene backbone to obtain anion receptors. XBs can have comparable strength to HBs, but XB donors do not have acidic H-atoms, as they interact with anions using halogen atoms. This makes XB-based anionophores less likely to dissipate pH gradients compared to anionophores relying on HBs. A series of calixarene-based molecules were designed and synthesized to screen them for anion transport. One of our molecules was able to selectively transport chloride over protons. In this poster, I will present the compounds and their transport results. |
