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Prevalence and factors associated with carriage of Pfmdr1 polymorphisms among pregnant women receiving intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and artemether-lumefantrine for malaria treatment in Burkina Faso.

par Natama, Hamtandi Magloire;Rouamba, Toussaint ;Bazié, Djamina Line Cerine;Samadoulougou, Sekou;Coulibaly-Traoré, Maminata;Tinto, Halidou;Kirakoya, Fati
Référence Malaria journal, 19, 1, page (399)
Publication Publié, 2020-11-01

Article révisé par les pairs

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Résumé :

Single nucleotide polymorphisms occurring in the Plasmodium falciparum multidrug resistant gene 1 (pfmdr1) are known to be associated with aminoquinoline resistance and, therefore, represent key P. falciparum markers for monitoring resistance both in susceptible groups (children under 5 years old and pregnant women) and in the general population. This study aimed to determine prevalence and factors associated with the carriage of pfmdr1 N86Y, Y184F and D1246Y polymorphisms among pregnant women in a setting of high malaria transmission in Burkina Faso.