Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1.

Köhler, Arnaud; Delbauve, Sandrine; Smout, Justine; Torres, David; Flamand, Véronique

doi:doi/10.1136/gutjnl-2019-319700

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Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1.

par Köhler, Arnaud

Référence Gut
Publication Publié, 2020-06-01

Article révisé par les pairs

Résumé :

Induction of immune protection against pathogens is particularly crucial during the neonatal period dominated by anti-inflammatory and tolerance immunity. The preclinical study was carried out to determine whether environmental factors such as microbiota may influence early life immunity by impacting the development and the functional maturation of precursors of type 1 conventional dendritic cells (pre-cDC1), endowed with regulatory properties.

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