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Cerebral autoregulation and neurovascular coupling are progressively impaired during septic shock: an experimental study.

par Ferlini, Lorenzo ;Su, FUHONG ;Creteur, Jacques ;Taccone, Fabio ;Gaspard, Nicolas
Référence Intensive care medicine experimental, 8, 1, page (44)
Publication Publié, 2020-08

Article révisé par les pairs

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Résumé :

Alteration of the mechanisms of cerebral blood flow (CBF) regulation might contribute to the pathophysiology of sepsis-associated encephalopathy (SAE). However, previous clinical studies on dynamic cerebral autoregulation (dCA) in sepsis had several cofounders. Furthermore, little is known on the potential impairment of neurovascular coupling (NVC) in sepsis. The aim of our study was to determine the presence and time course of dCA and NVC alterations in a clinically relevant animal model and their potential impact on the development of SAE.