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Hidradenitis suppurativa is associated with childhood and lifetime traumatic events: a case–control study

par Gielen, Sanne ;Janmohamed, Sherief S.R.;Van Laethem, A.;Del Marmol, Véronique ;Suppa, Mariano ;Gutermuth, Jan;Willemsen, Ria
Référence JEADV. Journal of the European Academy of Dermatology and Venereology
Publication Publié, 2020-12-01

Article révisé par les pairs

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Résumé :

Background: Negative life events in childhood can increase the susceptibility to autoimmune and inflammatory diseases. Hidradenitis suppurativa (HS) is a systemic inflammatory disease affecting the apocrine sweat glands, characterized by abscesses, fistulas and inflammatory nodules. It is unknown whether adult HS is associated with traumatic events. Objective: To investigate the association between childhood and total lifetime traumatic events and the presence of HS. Methods: We conducted a matched (1 : 3) case–control study with 71 HS patients and 213 controls. Patients were matched on age, gender and level of education. Questionnaires on general and demographic information, as well as the Traumatic Experience Checklist and the Hospital Anxiety and Depression Scale, were completed. Results: The number of traumatic events (OR: 1.20 per trauma, P value < 0.05), and childhood traumatic events (yes vs. no, OR 3.59, P value < 0.05) and the number of childhood traumatic events (OR 1.35 per trauma, P value < 0.05) were correlated with an increased risk of developing HS. Detailed analysis showed that childhood emotional traumatic events (OR 5.03, P value < 0.05) were significantly associated with the development of HS. Conclusion: Number of lifetime traumatic events and childhood traumatic events are associated with HS. This association is strongest for emotional childhood traumas. The increased prevalence of childhood traumas in HS patients can be one of the underlying mechanisms leading to systemic inflammation in these patients.