par Tozatto-Maio, Karina;Torres, Margareth Afonso;Degaide, Neifi Hassan Saloum;Cardoso, Juliana Fernandes;Volt, Fernanda;Pinto, Ana Cristina Silva;Oliveira, Danielli;Elayoubi, Hanadi;Kashima, Simone;Loiseau, Pascale;Veelken, Hendrik;Ferster, Alina ;Cappelli, Barbara;Rodrigues, Evandra Strazza;Scigliuolo, Graziana Maria;Kenzey, Chantal;Ruggeri, A.;Rocha, Vanderson Geraldo;Simões, Belinda Pinto;Tamouza, Ryad;Gluckman, Éliane E.
Référence Biology of blood and marrow transplantation
Publication Publié, 2020-06-01
Référence Biology of blood and marrow transplantation
Publication Publié, 2020-06-01
Article révisé par les pairs
Résumé : | Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Hematopoietic stem cell transplantation (HCT) is the sole curative therapy for SCD, but few patients will have a matched sibling donor. Patients with SCD are mostly of African origin and thus are less likely to find a matched unrelated donor in international registries. Using HaploStats, we estimated HLA haplotypes for 185 patients with SCD (116 from a Brazilian center and 69 from European Society for Blood and Marrow Transplantation [EBMT] centers) and classified the ethnic origin of haplotypes. Then we assessed the probability of finding an HLA-matched unrelated adult donor (MUD), considering loci A, B, and DRB1 (6/6), in international registries. Most haplotypes were African, but Brazilians showed a greater ethnic admixture than EBMT patients. Nevertheless, the chance of finding at least one 6/6 potential allelic donor was 47% for both groups. Most potential allelic donors were from the US National Marrow Donor Program registry and from the Brazilian REDOME donor registry. Although the probability of finding a donor is higher than previously reported, strategies are needed to improve ethnic diversity in registries. Moreover, predicting the likelihood of having an MUD might influence SCD management. |