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Test–retest reliability of the Friedreich’s ataxia rating scale

par Rummey, Christian;Zesiewicz, Theresa T.A.;Perez-Lloret, Santiago;Farmer, Jennifer;Pandolfo, Massimo ;Lynch, David
Référence Annals of clinical and translational neurology
Publication Publié, 2020

Article révisé par les pairs

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Résumé :

The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.