par Papadopoulou, Maria ;Dimova, Tanya ;Shey, Muki;Briel, Libby;Veldtsman, Helen;Khomba, Nondumiso;Africa, Hadn;Steyn, Marcia;Hanekom, Willem WA;Scriba, Thomas TJ;Nemes, Elisa;Vermijlen, David
Référence Proceedings of the National Academy of Sciences of the United States of America, 117, 31, page (18638-18648)
Publication Publié, 2020-08-01
Référence Proceedings of the National Academy of Sciences of the United States of America, 117, 31, page (18638-18648)
Publication Publié, 2020-08-01
Article révisé par les pairs
Résumé : | Vγ9Vδ2 T cells are a major human blood γδ T cell population that respond in a T cell receptor (TCR)-dependent manner to phosphoantigens which are generated by a variety of microorganisms. It is not clear how Vγ9Vδ2 T cells react toward the sudden microbial exposure early after birth. We found that human Vγ9Vδ2 T cells with a public/shared fetal-derived TCR repertoire expanded within 10 wk postpartum. Such an expansion was not observed in non-Vγ9Vδ2 γδ T cells, which possessed a private TCR repertoire. Furthermore, only the Vγ9Vδ2 T cells differentiated into potent cytotoxic effector cells by 10 wk of age, despite their fetal origin. Both the expansion of public fetal Vγ9Vδ2 T cells and their functional differentiation were not affected by newborn vaccination with the phosphoantigen-containing bacillus Calmette-Guérin (BCG) vaccine. These findings suggest a strong and early priming of the public fetal-derived Vγ9Vδ2 T cells promptly after birth, likely upon environmental phosphoantigen exposure. |