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Role of Lipocalin-type prostaglandin D synthase in experimental osteoarthritis.

par Najar, Mehdi ;Ouhaddi, Yassine;Paré, Frédéric;Lussier, Bertrand;Urade, Yoshihiro;Kapoor, Mohit;Pelletier, Jean-Pierre;Martel-Pelletier, Johanne;Benderdour, Mohamed;Fahmi, Hassan
Référence Arthritis & rheumatology (Hoboken, N.J.)
Publication Publié, 2020-04

Article révisé par les pairs

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Résumé :

Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the formation of prostaglandin D2 (PGD2), which has important roles in inflammation and cartilage metabolism. The aim of this study was to investigate the role of L-PGDS in the pathogenesis of OA using an experimental mouse model.