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Effectiveness and persistence of vedolizumab in patients with inflammatory bowel disease: Results from the Belgian REal-LIfe study with VEdolizumab (be-RELIVE)

par Reenaers, Catherine;Cremer, Anneline ;Dewit, Olivier;De Vroey, Bénédicte;Van Moerkercke, W.;Bossuyt, Peter;Muls, Vinciane ;Imschoot, Johan;Block, S.;Hantson, Anne Lise;Van Hootegem, Ph
Référence Acta Gastro-Enterologica Belgica (English ed.), 83, 1, page (15-23)
Publication Publié, 2020

Article révisé par les pairs

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Résumé :

Background and study aims: Vedolizumab (VDZ) is a gut-selective integrin inhibitor used to treat Crohn’s disease (CD) and ulcerative colitis (UC). This retrospective study assessed effectiveness and treatment persistence of VDZ in a Belgian real-life cohort of CD and UC patients. Patients and methods: CD and UC patients from 15 Belgian centers, who started VDZ between 01/09/2015 and 31/06/2016 and attended ≥1 visit after the first VDZ infusion, were included. Data were collected before first infusion, at week (W)10, W14 (CD patients only), month (M)6 and last follow-up. Treatment response and remission rates (changes in disease activity scores) and treatment persistence (Kaplan-Meier analysis) were assessed. Results: Of the 348 patients receiving at least one dose of VDZ, 325 (202 CD, 45 biologic-naïve; and 123 UC, 42 biologic-naïve) patients were included in data analyses. At M6, 87.6% (176/201) of CD and 86.1% (105/122) of UC patients were still on VDZ treatment, 75.6% (34/45) and 83.9% (26/31) achieved clinical response, and 66.7% (44/66) and 42.9% (15/35) were in remission. At M6 remission rates was significantly higher while response rates tended to be higher among biologic-naïve versus biologic-failure CD patients. Conclusions: VDZ offers an effective treatment option in real-life settings and treatment effectiveness appears higher in biologic-naïve versus biologic-failure CD patients.