Genome-wide Association Study for Alcohol-related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1.

Innes, Hamish; Buch, Stephan; Hutchinson, Sharon; Guha, Indra Neil; Morling, Joanne JR; Barnes, Elleanor; Irving, Will; Forrest, Ewan; Pedergnan, Vincent; Goldberg, David; Aspinall, Esther; Barclay, Stephan; Hayes, Peter; Dillon, John; Nischalke, Hans Dieter; Lutz, Philipp; Spengler, Ulrich; Fischer, Janett; Berg, Thomas; Brosch, Mario; Eyer, Florian; Datz, Christian; Mueller, Sebastian; Peccerella, Teresa; Deltenre, Pierre; Marot, Astrid; Soyka, Michael; McQuillin, Andrew; Morgan, Marsha Y; Hampe, Jochen; Stickel, Felix

doi:doi/10.1053/j.gastro.2020.06.014

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Article révisé par les pairs

Résumé :

Little is known about genetic factors that affect development of alcohol-related cirrhosis. We performed a genome-wide association study (GWAS) of samples from the United Kingdom Biobank (UKB) to identify polymorphisms associated with risk of alcohol-related liver disease.

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