par Leduc, Dimitri ;De Vuyst, Paul ;Lheureux, Philippe ;Gevenois, Pierre-Alain ;Jacobovitz, Danielle;Yernault, Jean Claude
Référence Chest, 104, page (1620-1623)
Publication Publié, 1993
Référence Chest, 104, page (1620-1623)
Publication Publié, 1993
Lettre à l'éditeur
Résumé : | Two very similar cases of drug-induced pneumonitis complicating treatment of rheumatoid arthritis with low-dose methotrexate are presented. Diagnosis was suggested by clinical history and findings, but the bronchoalveolar lavage showed a high percentage of neutrophils, an unusual feature in methotrexate-induced pneumonitis. Transbronchial lung biopsies (TBB) confirmed the diagnosis by showing interstitial lymphocytic infiltrate with microgranulomas. Although histologic findings are not strictly pathognomonic, when a differential diagnosis has to be made with infectious and rheumatoid lung disease, TBB appears to be of great promise. |