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Transmembrane transport of copper(I) by imidazole-functionalised calix[4]arenes

par Renier, Nathan ;Reinaud, Olivia;Jabin, Ivan ;Valkenier, Hennie
Référence ChemRxiv
Publication Publié, 2020-04-29

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Résumé :

Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu+ transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu+ into chloroform. Transmembrane transport of Cu+ into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu+ ionophores for biomedical applications.