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Orally administered paracetamol does not act locally in the rat formalin test: evidence for a supraspinal, serotonin-dependent antinociceptive mechanism.

par Bonnefont, Jérôme ;Alloui, Abdelkrim;Chapuy, Eric;Clottes, Eric;Eschalier, Alain
Référence Anesthesiology, 99, 4, page (976-981)
Publication Publié, 2003-10

Article révisé par les pairs

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Résumé :

The mechanism of action of paracetamol (acetaminophen) remains elusive because it is still under discussion as to whether it acts locally and/or centrally. The primary aim of this study was to clarify its site(s) of action (central and/or local) using the rat formalin test.