Résumé : Periodically driven quantum systems are currently explored in view of realizing novel many-body phases of matter. This approach is particularly promising in gases of ultracold atoms, where sophisticated shaking protocols can be realized and interparticle interactions are well controlled. The combination of interactions and time-periodic driving, however, often leads to uncontrollable heating and instabilities, potentially preventing practical applications of Floquet engineering in large many-body quantum systems. In this work, we experimentally identify the existence of parametric instabilities in weakly interacting Bose-Einstein condensates in strongly driven optical lattices through momentum-resolved measurements, in line with theoretical predictions. Parametric instabilities can trigger the destruction of weakly interacting Bose-Einstein condensates through the rapid growth of collective excitations, in particular in systems with weak harmonic confinement transverse to the lattice axis. Understanding the onset of parametric instabilities in driven quantum matter is crucial for determining optimal conditions for the engineering of modulation-induced many-body systems.