Résumé : Atmospheric dust is an integral component of the Earth system with major implications for the climate, biosphere and public health. In this context, identifying and quantifying the provenance and the processes generating the various types of dust found in the atmosphere is paramount. Isotopic signatures of Pb, Nd, Sr, Zn, Cu and Fe are commonly used as sensitive geochemical tracers. However, their combined use is limited by the lack of (a) a dedicated chromatographic protocol to separate the six elements of interest for low-mass samples and (b) specific reference materials for dust. Indeed, our work shows that USGS rock reference materials BHVO-2, AGV-2 and G-2 are not applicable as substitute reference materials for dust. We characterised the isotopic signatures of these six elements in dust reference materials ATD and BCR-723, representatives of natural and urban environments, respectively. To achieve this, we developed a specific procedure for dust, applicable in the 4–25 mg mass range, to separate the six elements using a multi-column ion-exchange chromatographic method and MC-ICP-MS measurements.