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Timing of Intradermal Rabies Pre-exposure Prophylaxis Injections: Immunological Effect on Vaccination Response.

par Van Nieuwenhove, Mathias MDM;Damanet, Benjamin ;Soentjens, Patrick
Référence Military medicine, 184, 9-10, page (e515-e521)
Publication Publié, 2019-10-01

Article révisé par les pairs

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Résumé :

Rabies remains a global threat, with annually over 59,000 deaths. Intradermal (ID) pre-exposure prophylaxis (PrEP) is very efficient and reduces the need for rabies immunoglobulins. Not much is known about factors that influence the immune response to ID administered rabies vaccine. The aim of this study is to determine if variations in timing of vaccine administration and serology determination, age and gender have an influence on the levels of rabies virus neutralizing antibody (RVNA) after ID rabies vaccination.