• Citer

Prognostic and Predictive Impact of Beta-2 Adrenergic Receptor Expression in HER2-Positive Breast Cancer

par Caparica Bitton, Rafael ;Richard, François;Brandao, Marianna;Awada, Ahmad ;Sotiriou, Christos ;de Azambuja, Evandro
Référence Clinical breast cancer
Publication Publié, 2020-01-01

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

ADRB2 mediates trastuzumab resistance in preclinical models of HER2+ breast cancer. We evaluated ADRB2 gene expression as a prognostic and predictive biomarker in HER2+ early breast cancer patients. Opposing our initial hypothesis, a high ADRB2 expression may exert antiproliferative, antiangiogenic, and immunogenic effects, and thus be associated with a favorable prognosis in patients with HER2+ early breast cancer.