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Colour-sidedness in Gloucester cattle is associated with a complex structural variant impacting regulatory elements downstream of KIT

par Artesi, Maria;Tamma, Nico;Deckers, M.;Karim, Latifa;Coppieters, Wouter;Van Den Broeke, Anne ;Georges, Michel;Charlier, Carole;Durkin, Keith
Référence Animal genetics
Publication Publié, 2020-07-01

Article révisé par les pairs

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Résumé :

Colour-sidedness is a striking coat colour pattern found in a number of cattle breeds, typically characterised by a white stripe that extends along the back, head and belly of the animal. This dominant phenotype is caused by two related translocations (Cs6 and Cs29) that alter a region downstream of the KIT gene. Gloucester cattle are native to the UK and are known for an unusual colour-sided pattern that does not extend to the head. We carried out whole-genome sequencing of two Gloucester bulls as well as colour-sided Irish Moiled, British White and Pustertaler Sprinzen for comparison. We found that the Gloucester cattle also have a complex structural variant downstream of KIT, which overlaps the regions involved in Cs6 and Cs29 . All three alleles potentially disrupt a number of putative regulatory elements downstream of KIT. These results complement and expand on the recently published work focused on the Pinzgauer breed from Austria, a carrier of the same colour-sided pattern as seen in Gloucester cattle.